Born in Atlanta, Williams-Omilami is the daughter of activist Hosea Williams and Georgia State Representative Juanita T. Williams. Williams-Omilami's young life was spent with the Civil Rights Movement of the 1950s, 1960s and 1970s. She created the People's Survival Theatre. Williams-Omilami directed and acted as her husband’s, Afemo Omilami, career grew. Williams-Omilami graduated from Hampton University with a BA in Theatre.

Williams-Omilami worked in the background of her father's Hosea Feed The Hungry and Homeless efforts. In November 2000, she  became the organization's CEO, expanding the organization from a budget of $200,000 to over $1.5 million working to meet the basic needs of the working poor and homeless. Ms. Omilami, an activities, entrepreneur, actress, and philanthropist is an Honorary Member of Zeta Phi Beta Sorority, Incorporated.